RESUMO
BACKGROUND: Cutaneous carcinosarcoma is a rare biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Data on the clinical and histopathologic characteristics of this tumor are scarce. The objective of this study was to describe the clinicopathologic and immunohistochemical features of cutaneous carcinosarcoma. METHODS: A descriptive retrospective study was conducted in a tertiary care hospital from Spain. We reviewed the records of eight patients with cutaneous carcinosarcoma who were diagnosed from 2009 to 2019. RESULTS: The mean patient age at diagnosis was 72.13 years (range 44-91 years), and there was a male predilection (6 cases). The most common site of cutaneous carcinosarcoma was the head and neck (5 cases). Carcinosarcomas demonstrated variable histopathological and immunohistochemical features. Follow-up was available for 7-8 patients. There were two cases of local recurrence and one case of metastasis. Two patients died from the tumor during the entire follow-up. CONCLUSIONS: Although the number of cases in this study was limited, our results provide valuable insight into the clinical, histopathologic, and immunohistochemical characteristics of primary cutaneous carcinosarcoma.
Assuntos
Carcinossarcoma/metabolismo , Carcinossarcoma/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia , Actinas/metabolismo , Adulto , Idoso de 80 Anos ou mais , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Carcinossarcoma/secundário , Carcinossarcoma/cirurgia , Desmina/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Queratina-1/metabolismo , Queratina-3/metabolismo , Masculino , Proteínas de Ligação à Região de Interação com a Matriz/metabolismo , Proteínas de Membrana/metabolismo , Pessoa de Meia-Idade , Miogenina/metabolismo , Neprilisina/metabolismo , Estudos Retrospectivos , Neoplasias Cutâneas/cirurgia , Fatores de Transcrição/metabolismo , alfa 1-Antitripsina/metabolismoRESUMO
No disponible
Assuntos
Humanos , Masculino , Adulto , Tatuagem/efeitos adversos , Psoríase/complicações , Dermatopatias/induzido quimicamente , Psoríase/tratamento farmacológico , Corticosteroides/uso terapêutico , Vitamina D/uso terapêutico , Traumatismos do Braço/induzido quimicamente , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia , Pele/fisiopatologia , Ferimentos e Lesões/fisiopatologia , Administração TópicaRESUMO
No disponible
